David Kirby: Metals, Myelin & Mitochondria: Pathways To Autism?
David Kirby: Metals, Myelin & Mitochondria: Pathways To Autism? DVD VIDEO SEALED
Movie
DVD
Autism Today
2011
DVD
$49.99
Share:
DAVID KIRBY: METALS, MYELIN & MITOCHONDRIA: PATHWAYS TO AUTISM?
This insightful presentation explores the potential links between metals, myelin, and mitochondria in relation to the development of autism spectrum disorders (ASD).
Metals and Their Role in Neurological Health
Metals such as mercury, lead, and aluminum have long been studied for their neurotoxic effects, especially during critical periods of brain development. In the context of autism, abnormal accumulation or exposure to certain heavy metals may disrupt normal neurological processes. Essential metals like iron, copper, and zinc are also critically involved in brain function, but imbalances in these can contribute to oxidative stress and inflammation, potentially impacting the developing brain.
Researchers have found that:
Exposure to toxic metals can interfere with neurotransmitter function, altering communication between neurons.
Some metals influence gene expression related to brain development, possibly affecting pathways associated with autism.
Detoxification mechanisms in children with autism might be impaired, leading to greater vulnerability to metal toxicity.
Myelin and Its Significance in Autism
Myelin is the protective sheath surrounding nerve fibers, essential for rapid and efficient transmission of electrical signals in the nervous system. Proper myelination is crucial for brain connectivity and cognitive functions, both areas often affected in individuals with autism.
Key points about myelin in autism include:
Abnormalities in myelin structure or formation can lead to disrupted neural connectivity, which is a hallmark observed in many autism studies.
Changes in myelin-related genes and proteins have been documented in some autistic individuals, suggesting a role in the disorder's pathology.
Environmental factors, including exposure to metals, may negatively influence myelin development and maintenance.
The Role of Mitochondria in Brain Function and Autism
Mitochondria, the cellular “powerhouses,” generate energy required for almost all cellular activities. Brain cells demand high energy, making proper mitochondrial function vital for neural health.
Emerging evidence suggests mitochondrial dysfunction may be involved in autism:
Energy Deficit: Impaired mitochondrial activity can lead to insufficient energy production, affecting neuronal growth and signaling.
Oxidative Stress: Mitochondrial dysfunction may cause excessive production of reactive oxygen species (ROS), damaging cells including neurons.
Inflammation: Damaged mitochondria can trigger inflammatory pathways, potentially exacerbating neurological symptoms linked to ASD.
Interconnected Pathways: How Metals, Myelin, and Mitochondria Might Contribute to Autism
David Kirby’s presentation highlights the complex interplay among these three factors, hypothesizing that they may converge to influence the onset and progression of autism spectrum disorders. For example, metal exposure might disrupt mitochondrial function, which in turn could impair myelin integrity, ultimately leading to neural communication deficits characteristic of ASD.
This multifactorial perspective stresses the importance of:
Further research into environmental and biological interactions impacting autism development.
Potential diagnostic biomarkers, such as metal levels or mitochondrial markers, to identify affected individuals early.
Developing targeted therapies aimed at restoring mitochondrial function or protecting myelin from damage.
In summary, the pathways involving metals, myelin, and mitochondria offer promising avenues to deepen our understanding of autism spectrum disorders and may pave the way for innovative approaches to treatment and prevention.
For DVD Player (North American NTSC)
This insightful presentation explores the potential links between metals, myelin, and mitochondria in relation to the development of autism spectrum disorders (ASD).
Metals and Their Role in Neurological Health
Metals such as mercury, lead, and aluminum have long been studied for their neurotoxic effects, especially during critical periods of brain development. In the context of autism, abnormal accumulation or exposure to certain heavy metals may disrupt normal neurological processes. Essential metals like iron, copper, and zinc are also critically involved in brain function, but imbalances in these can contribute to oxidative stress and inflammation, potentially impacting the developing brain.
Researchers have found that:
Exposure to toxic metals can interfere with neurotransmitter function, altering communication between neurons.
Some metals influence gene expression related to brain development, possibly affecting pathways associated with autism.
Detoxification mechanisms in children with autism might be impaired, leading to greater vulnerability to metal toxicity.
Myelin and Its Significance in Autism
Myelin is the protective sheath surrounding nerve fibers, essential for rapid and efficient transmission of electrical signals in the nervous system. Proper myelination is crucial for brain connectivity and cognitive functions, both areas often affected in individuals with autism.
Key points about myelin in autism include:
Abnormalities in myelin structure or formation can lead to disrupted neural connectivity, which is a hallmark observed in many autism studies.
Changes in myelin-related genes and proteins have been documented in some autistic individuals, suggesting a role in the disorder's pathology.
Environmental factors, including exposure to metals, may negatively influence myelin development and maintenance.
The Role of Mitochondria in Brain Function and Autism
Mitochondria, the cellular “powerhouses,” generate energy required for almost all cellular activities. Brain cells demand high energy, making proper mitochondrial function vital for neural health.
Emerging evidence suggests mitochondrial dysfunction may be involved in autism:
Energy Deficit: Impaired mitochondrial activity can lead to insufficient energy production, affecting neuronal growth and signaling.
Oxidative Stress: Mitochondrial dysfunction may cause excessive production of reactive oxygen species (ROS), damaging cells including neurons.
Inflammation: Damaged mitochondria can trigger inflammatory pathways, potentially exacerbating neurological symptoms linked to ASD.
Interconnected Pathways: How Metals, Myelin, and Mitochondria Might Contribute to Autism
David Kirby’s presentation highlights the complex interplay among these three factors, hypothesizing that they may converge to influence the onset and progression of autism spectrum disorders. For example, metal exposure might disrupt mitochondrial function, which in turn could impair myelin integrity, ultimately leading to neural communication deficits characteristic of ASD.
This multifactorial perspective stresses the importance of:
Further research into environmental and biological interactions impacting autism development.
Potential diagnostic biomarkers, such as metal levels or mitochondrial markers, to identify affected individuals early.
Developing targeted therapies aimed at restoring mitochondrial function or protecting myelin from damage.
In summary, the pathways involving metals, myelin, and mitochondria offer promising avenues to deepen our understanding of autism spectrum disorders and may pave the way for innovative approaches to treatment and prevention.
For DVD Player (North American NTSC)
WHAT YOU GET:
This item is for the original media, and includes only the media (ie. CD, floppy ...) UNLESS specifically stated above and/or in the title. If more than just the media is included, it will state which items are (ie. box, manual, etc ). Items that come in a sleeve refer to a generic CD sleeve (typically white) and will be sent with shipping protection to avoid damage during transit. If available, we will also send the front and/or back CD inserts if in stock. If these are important to you, please message us to verify we have them available to send. Please do not assume items are included other than what's stated. Again, ask questions PRIOR to purchasing if you have any concerns.
IMAGES:
All images/pictures are stock photos and are for reference only, mainly to show the type of game you will be getting. Please read "WHAT YOU GET" for what is included with the media. Screenshots may vary based on your own computer system, video card, monitor, etc.
COMPATIBILITY:
Computers are like people, each one is different. Unlike console games, a computer game may install and work flawlessly on one system but may need adjustments on another. This is due to a variety of factors, mainly the OS platform running, video card you have, drivers, protection software installed, etc. Many times manufacturers release updates to games to fix bugs and add enhancements. We would be happy to help get the game going on your computer, but ultimately compatibility issues are the responsibility of the buyer. We suggest going to Google and searching for the name of the game along with the words "system requirements" to determine if your system is suitable. Ultimately, we are not responsible for software compatibility problems or publisher's errors.
PLATFORM:
Stated within the auction is what platform the game will work on (ie. Windows, Mac, Linux...) This is a generic statement and specific platform versions (ie. XP, Vista...) will have to be researched by the buyer. Games that came out PRIOR to XP or higher will not specifically state they will work on that release, but only because they came out before those versions were made. Many, if not most, will work on XP or higher with a few quick adjustments. We provide instructions with all items purchased on how to do this adjustment using the Program Compatibility Wizard. If we find out that an item will definately not work on a specific version, we will state it. For DOS games, you may need to play it with a free DOSbox program if the Program Compatibility Wizard does not work.
64-Bit Windows OS Systems:
For 64-bit Operating Systems, older games most likely will NOT work due to 64-bit systems not being able to run 16-bit programming code (most games prior to 2000). For DOS games, you may need to play it with a free DOSbox program.
Macintosh Systems:
For Macintosh programs, most older games will need to be run in Classic Environment if you have a MAC OS X 10.0 - 10.4 version. Please research Google on how to do this, or send us a message for information prior to purchasing. If your MAC OS system doesn't support Classic Environment (ie. MAC OS X 10.5 or Higher OR Intel Macs), you will have to try running it using the free program called SheepShaver, but compatibility is not ensured. Please research prior to purchasing or ask questions.
MEDIA FORMAT:
Please verify you have the required hardware in order to use the specified media (ie. CD, DVD, floppy drives, etc.) If the item comes as a floppy disc, make sure you have either the needed 3.5" floppy drive or the bigger and older 5.25" floppy drive.
RECOMMENDATIONS FOR A SMOOTH PURCHASE:
Ask questions PRIOR to purchasing an order to avoid any confusion.
Be patient if there are problems during installation or gameplay. Typically someone else has
already ran into that problem and has listed a solution online. Contact us and we will do our best to help.
Be sure to update your video card drivers and search for updates to the game from the manufacturer.
This item is for the original media, and includes only the media (ie. CD, floppy ...) UNLESS specifically stated above and/or in the title. If more than just the media is included, it will state which items are (ie. box, manual, etc ). Items that come in a sleeve refer to a generic CD sleeve (typically white) and will be sent with shipping protection to avoid damage during transit. If available, we will also send the front and/or back CD inserts if in stock. If these are important to you, please message us to verify we have them available to send. Please do not assume items are included other than what's stated. Again, ask questions PRIOR to purchasing if you have any concerns.
IMAGES:
All images/pictures are stock photos and are for reference only, mainly to show the type of game you will be getting. Please read "WHAT YOU GET" for what is included with the media. Screenshots may vary based on your own computer system, video card, monitor, etc.
COMPATIBILITY:
Computers are like people, each one is different. Unlike console games, a computer game may install and work flawlessly on one system but may need adjustments on another. This is due to a variety of factors, mainly the OS platform running, video card you have, drivers, protection software installed, etc. Many times manufacturers release updates to games to fix bugs and add enhancements. We would be happy to help get the game going on your computer, but ultimately compatibility issues are the responsibility of the buyer. We suggest going to Google and searching for the name of the game along with the words "system requirements" to determine if your system is suitable. Ultimately, we are not responsible for software compatibility problems or publisher's errors.
PLATFORM:
Stated within the auction is what platform the game will work on (ie. Windows, Mac, Linux...) This is a generic statement and specific platform versions (ie. XP, Vista...) will have to be researched by the buyer. Games that came out PRIOR to XP or higher will not specifically state they will work on that release, but only because they came out before those versions were made. Many, if not most, will work on XP or higher with a few quick adjustments. We provide instructions with all items purchased on how to do this adjustment using the Program Compatibility Wizard. If we find out that an item will definately not work on a specific version, we will state it. For DOS games, you may need to play it with a free DOSbox program if the Program Compatibility Wizard does not work.
64-Bit Windows OS Systems:
For 64-bit Operating Systems, older games most likely will NOT work due to 64-bit systems not being able to run 16-bit programming code (most games prior to 2000). For DOS games, you may need to play it with a free DOSbox program.
Macintosh Systems:
For Macintosh programs, most older games will need to be run in Classic Environment if you have a MAC OS X 10.0 - 10.4 version. Please research Google on how to do this, or send us a message for information prior to purchasing. If your MAC OS system doesn't support Classic Environment (ie. MAC OS X 10.5 or Higher OR Intel Macs), you will have to try running it using the free program called SheepShaver, but compatibility is not ensured. Please research prior to purchasing or ask questions.
MEDIA FORMAT:
Please verify you have the required hardware in order to use the specified media (ie. CD, DVD, floppy drives, etc.) If the item comes as a floppy disc, make sure you have either the needed 3.5" floppy drive or the bigger and older 5.25" floppy drive.
RECOMMENDATIONS FOR A SMOOTH PURCHASE:
SHIPPING:
We typically ship all items out within 1-2 business days after payment is received. In regards to the stated shipping and handling, remember that these costs include more than just postage.
International buyers please email/chat with us to determine if you are eligible for shipping of a specific product. If you are, then international buyers not shipping to an address within the U.S. can expect their orders to take anywhere from 5 days to 4 weeks to be received, depending on how fast/well USPS is moving. Additionally, international orders typically have to go through governmental customs, which can delay the arrival process. Import duties, taxes, and charges are not included in the item price or shipping cost. These charges are the buyer's responsibility. Please check with your country's customs office to determine what these additional costs will be prior to buying. Customs fees are normally charged by the shipping company or collected when you pick the item up. These fees are not additional shipping charges.
We typically ship all items out within 1-2 business days after payment is received. In regards to the stated shipping and handling, remember that these costs include more than just postage.
International buyers please email/chat with us to determine if you are eligible for shipping of a specific product. If you are, then international buyers not shipping to an address within the U.S. can expect their orders to take anywhere from 5 days to 4 weeks to be received, depending on how fast/well USPS is moving. Additionally, international orders typically have to go through governmental customs, which can delay the arrival process. Import duties, taxes, and charges are not included in the item price or shipping cost. These charges are the buyer's responsibility. Please check with your country's customs office to determine what these additional costs will be prior to buying. Customs fees are normally charged by the shipping company or collected when you pick the item up. These fees are not additional shipping charges.
